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Abstract
Alcoholic encephalopathies remain a serious complication of chronic alcohol dependence and are associated with high levels of disability and poor prognosis. Therapeutic outcomes largely depend on the timeliness and adequacy of pathogenetic treatment. Korsakov-type alcoholic encephalopathy most commonly develops during the resolution of severe alcohol withdrawal delirium and is closely linked to thiamine deficiency. This study evaluates the clinical effectiveness of thiamine megadoses compared to standard complex therapy in patients with Korsakov syndrome following prolonged alcoholic delirium. The findings demonstrate that high-dose thiamine therapy contributes to faster regression of psychopathological symptoms, shorter duration of consciousness disorders, and more pronounced recovery of neurological functions.
References
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