INSULIN RESISTANCE AS A CENTRAL MECHANISM IN METABOLIC SYNDROME: PATHOPHYSIOLOGY, CLINICAL IMPLICATIONS, AND THERAPEUTIC STRATEGIES
Vol. 2 No. 1 (2026), Articles
Vol. 2 No. 1 (2026)

INSULIN RESISTANCE AS A CENTRAL MECHANISM IN METABOLIC SYNDROME: PATHOPHYSIOLOGY, CLINICAL IMPLICATIONS, AND THERAPEUTIC STRATEGIES

Articles
Published 2026-01-08
Akmal Ziyadullayev Xusniddin oʻgʻli
Residents of the clinical residency of the endocrinology department of the Samarkand State Medical University
Umidjon Abdujabborov Yunusovich
Residents of the clinical residency of the endocrinology department of the Samarkand State Medical University
Gulzoda Negmatova Shuhratovna
Department of endocrinology, Samarkand State Medical Universit
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Keywords

Insulin resistance, metabolic syndrome, pathophysiology, cardiovascular risk, type 2 diabetes mellitus, therapeutic strategies

How to Cite

Ziyadullayev Xusniddin oʻgʻli, A., Abdujabborov Yunusovich, U., & Negmatova Shuhratovna, G. (2026). INSULIN RESISTANCE AS A CENTRAL MECHANISM IN METABOLIC SYNDROME: PATHOPHYSIOLOGY, CLINICAL IMPLICATIONS, AND THERAPEUTIC STRATEGIES. INTERNATIONAL CONFERENCE ON SCIENCE AND INNOVATIVE RESEARCH, 2(1), 17–21. Retrieved from https://scienceinno.org/index.php/iccir/article/view/54
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Abstract

Metabolic syndrome is a multifactorial disorder characterized by a combination of central obesity, dyslipidemia, hypertension, and impaired glucose metabolism, all of which markedly increase the risk of type 2 diabetes mellitus and cardiovascular disease. Insulin resistance plays a pivotal role in the pathogenesis of metabolic syndrome by disrupting normal glucose and lipid homeostasis and promoting chronic low-grade inflammation and endothelial dysfunction. This study aims to evaluate insulin resistance as the central mechanism underlying metabolic syndrome, to describe its pathophysiological basis, and to assess its clinical implications. A comprehensive review of clinical and experimental studies was conducted, focusing on diagnostic markers of insulin resistance, associated metabolic abnormalities, and current therapeutic strategies. The findings indicate a strong association between insulin resistance and all major components of metabolic syndrome, including visceral obesity, dyslipidemia, and hypertension. Lifestyle interventions such as dietary modification, weight reduction, and increased physical activity were shown to significantly improve insulin sensitivity, while pharmacological therapies further reduced metabolic and cardiovascular risk in high-risk individuals. In conclusion, targeting insulin resistance is essential for the effective prevention and management of metabolic syndrome and its long-term complications.

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